Cytotoxic T lymphocyte-associated antigen 4 rs231775 polymorphism and osteosarcoma
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چکیده
منابع مشابه
Cytotoxic T-lymphocyte-associated antigen-4.
Cancer immunotherapy relies on the ability of the immune system to target tumor-specific antigens to generate an immune response. This initial response requires both binding of the MHC/antigen peptide to T-cell receptor complex, along with a second costimulatory signal created by the binding of CD28 on the T cell, with B7 located on the antigen-presenting cell. Regulatory checkpoints, such as c...
متن کاملCytotoxic T-lymphocyte Associated Antigen-4 (CTLA-4) Polymorphism, Cancer, and Autoimmune Diseases
Immune system dysfunction is one of the key features in onset and development of cancer and autoimmunity. Cytotoxic T-lymphocyte-antigen-4 (CTLA-4), as a leader immune checkpoint plays a crucial effects in the regulation of immune suppression and tolerance. In this review, role of CTLA-4 and its three important polymorphisms (SNP), CTLA-4 +49A/G, CTLA-4 CT60 A/G and CTLA-4 −318C/T in developmen...
متن کاملCytotoxic T lymphocyte antigen 4 gene polymorphism associated with ST-segment elevation acute myocardial infarction.
BACKGROUND Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a particularly important molecule in down-regulating T-cell expansion and cytokine production. The purpose of the present study was to determine the frequency distribution of an A/G single nucleotide polymorphism at position 49 in exon 1 of the CTLA-4 gene, which may be a functional related-genetic risk marker for the development of ST-seg...
متن کاملDetection of Cytotoxic T-Lymphocyte Associated Antigen-4 Gene Polymorphism in Type 1 Diabetes Mellitus.
Type 1 diabetes is one of the most common chronic childhood illnesses. Interplay between genetic susceptibility and environmental factors is thought to provide the fundamental element for the disease. It has been shown that more than 40 genetic loci are associated with T1DM. Important one among these is the CTLA-4. This work aimed to detect Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4) g...
متن کاملthe cytotoxic t lymphocyte antigen-4 +49a/g single nucleotide polymorphism association with visceral leishmaniasis
conclusions according to the results, the polymorphisms within the +49 position of ctla-4 can be associated with vl and may be considered as risk factors for the disease. results our results indicated that both ctla-4 +49a/g polymorphisms were significantly associated with vl. materials and methods in this cross-sectional study, 88 patients with clinical presentations of vl, who were seropositi...
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ژورنال
عنوان ژورنال: Neoplasma
سال: 2017
ISSN: 1338-4317
DOI: 10.4149/neo_2017_218